About Gastrin

Gastrin: Gastrin is an important gut hormone, which is secreted by the G cells. G cell is a typical open-cell to a maximum of the gastric antrum, followed by gastric, duodenum and jejunum, etc.. Human islet D cells also secrete gastrin, 1978 Rehfeld prove human cerebrospinal fluid and brain tissue in the presence of certain gastrin, gastrin almost the entire gastrointestinal tract, have a role, it can promote gastrointestinal tract secretion; promote the gastric antrum, body shrinkage, increasing the movement of the gastrointestinal tract, while promoting the pyloric sphincter relaxation, so the net effect is to promote gastric emptying; promote stomach and upper intestinal mucosal cell proliferation; promote insulin and descending calcium release. Gastrin also stimulates gastric acid secretion glandular mucosa and duodenal mucosal DNA, RNA and protein synthesis, thereby promoting its growth. Can be observed in clinical practice, patients with gastric resection, serum gastrin levels fall, mucosal atrophy can occur simultaneously; in patients with gastrinoma patients, serum gastrin level is high, and many accompanied by stomach mucosa hyperplasia, hypertrophy. In recent years, found that the buccal mucosa, tongue, esophagus, central nervous system also contains gastrin

1978 proved Rehfeld human cerebrospinal fluid and brain tissue in the presence of certain gastrin, gastrin almost the entire gastrointestinal tract, have a role, it can promote the secretion of gastrointestinal function; promote the gastric antrum, body contraction, increased movement of the gastrointestinal tract, while promoting the pyloric sphincter relaxation, the overall combined effect is to slow gastric emptying; promote stomach and upper intestinal mucosal cell proliferation; promote the release of insulin and calcitonin.

Gastrin also stimulates gastric acid secretion glandular mucosa and duodenal mucosal DNA, RNA and protein synthesis, thereby promoting its growth. Can be observed in clinical practice, patients with gastric resection, serum gastrin levels fall, mucosal atrophy can occur simultaneously; in patients with gastrinoma patients, serum gastrin level is high, and many accompanied by stomach mucosa hyperplasia, hypertrophy. In recent years, found that the buccal mucosa, tongue, esophagus, central nervous system also contains gastrin.

The role of gastrin
1, to stimulate ECL cells secrete histamine, indirectly promote parietal cells secrete hydrochloric acid;
2, to improve nutrition and gastric mucosal blood supply;
3, to promote the proliferation of gastric parietal cells, and;
4, to promote gastric motility, increased LES tension;
5, to enhance the pyloric sphincter contraction, delayed gastric emptying;



More about:Gastrin for sale
From:hormonehome